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Solving the centriole disengagement puzzle

Nature Cell Biology volume 17, pages 35 (2015) | Download Citation

The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.

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Author information

Affiliations

  1. Andrew M. Fry is at the University of Leicester, Department of Biochemistry, Leicester LE1 9HN, UK

    • Andrew M. Fry

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Andrew M. Fry.

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DOI

https://doi.org/10.1038/ncb3087

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