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Cyclin C surprises in tumour suppression

Nature Cell Biology volume 16, pages 10311033 (2014) | Download Citation

Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.

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Author information

Affiliations

  1. Marianna Trakala and Marcos Malumbres are at Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

    • Marianna Trakala
    •  & Marcos Malumbres

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Marianna Trakala.

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DOI

https://doi.org/10.1038/ncb3055

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