Collective cell migration depends on multicellular mechanocoupling between leader and follower cells to coordinate traction force and position change. Co-registration of Rho GTPase activity and forces in migrating epithelial cell sheets now shows how RhoA controls leader–follower cell hierarchy, multicellular cytoskeletal contractility and mechanocoupling, to prevent ectopic leading edges and to move the cell sheet forward.
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Change history
14 March 2014
In the version of this News and Views article originally published, the author affiliations were incorrect. The correct affiliations are as follows: Peter Friedl, Katarina Wolf and Mirjam M. Zegers are in the Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. Peter Friedl is at the David H. Koch Center for Applied Research of Genitourinary Cancers, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. This has been corrected in all online versions of this News and Views article.
References
Hegerfeldt, Y., Tusch, M., Brocker, E. B. & Friedl, P. Cancer Res. 62, 2125–2130 (2002).
Li, L. et al. Cell. Mol. Life Sci. 69, 2779–2789 (2012).
Ng, M. R., Besser, A., Danuser, G. & Brugge, J. S. J. Cell Biol. 199, 545–563 (2012).
Omelchenko, T., Vasiliev, J. M., Gelfand, I. M., Feder, H. H. & Bonder, E. M. Proc. Natl Acad. Sci. USA 100, 10788–10793 (2003).
Theveneau, E. et al. Dev. Cell 19, 39–53 (2010).
Khalil, A. A. & Friedl, P. Integr. Biol. 2, 568–574 (2010).
Reffay, M. et al. Nat. Cell Biol. 16, 217–223 (2014).
Kurokawa, K. & Matsuda, M. Mol. Biol. Cell 16, 4294–4303 (2005).
Chrzanowska-Wodnicka, M. & Burridge, K. J. Cell Biol. 133, 1403–1415 (1996).
Iwanicki, M. P. et al. J. Cell Sci. 121, 895–905 (2008).
El-Sibai, M. et al. Exp. Cell Res. 314, 1540–1552 (2008).
Wang, X., He, L., Wu, Y. I., Hahn, K. M. & Montell, D. J. Nat. Cell Biol. 12, 591–597 (2010).
Sanz-Moreno, V. et al. Cell 135, 510–523 (2008).
Hidalgo-Carcedo, C. et al. Nat. Cell Biol. 13, 49–58 (2011).
Weber, G. F., Bjerke, M. A. & DeSimone, D. W. Dev. Cell 22, 104–115 (2012).
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Friedl, P., Wolf, K. & Zegers, M. Rho-directed forces in collective migration. Nat Cell Biol 16, 208–210 (2014). https://doi.org/10.1038/ncb2923
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DOI: https://doi.org/10.1038/ncb2923
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