In vivo time-lapse imaging and functional tests bring fresh evidence that the morphogen Hedgehog is conveyed to target cells via long filopodia extensions, dubbed cytonemes. This study provides the tools and conceptual framework to understand how cytonemes form and carry morphogens.
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Affiliations
James Briscoe and Jean-Paul Vincent are at the MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
- James Briscoe
- & Jean-Paul Vincent
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The authors declare no competing financial interests.
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Correspondence to James Briscoe or Jean-Paul Vincent.
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