News & Views | Published:

Crosstalk between mTOR complexes

Nature Cell Biology volume 15, pages 12631265 (2013) | Download Citation

The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Nat. Rev. Mol. Cell Biol. 12, 21–35 (2011).

  2. 2.

    et al. Mol. Cell 11, 1457–1466 (2003).

  3. 3.

    , , , & Mol. Cell 10, 151–162 (2002).

  4. 4.

    et al. Nature 408, 994–997 (2000).

  5. 5.

    & Cell Cycle 10, 2305–2316 (2011).

  6. 6.

    et al. Cell 127, 125–137 (2006).

  7. 7.

    , , , & Biochem. J. 439, 287–297 (2011).

  8. 8.

    et al. Curr. Biol. 10, 439–448 (2000).

  9. 9.

    et al. Dev. Cell 11, 859–871 (2006).

  10. 10.

    et al. Nature 431, 200–205 (2004).

  11. 11.

    et al. Science 332, 1317–1322 (2011).

  12. 12.

    et al. Science 332, 1322–1326 (2011).

  13. 13.

    et al. Nat. Cell Biol. 15, 1340–1350 (2013).

  14. 14.

    et al. Cell Metab. 17, 1009–1020 (2013).

  15. 15.

    et al. Nature 474, 609–615 (2011).

Download references

Author information

Affiliations

  1. Jianling Xie and Christopher G. Proud are at the Centre for Biological Sciences, Life Sciences Building (B85), University of Southampton, Southampton SO17 1BJ, UK

    • Jianling Xie
    •  & Christopher G. Proud

Authors

  1. Search for Jianling Xie in:

  2. Search for Christopher G. Proud in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Christopher G. Proud.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ncb2877

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing