CENP-E hangs on at dynamic microtubule ends

During mitosis, kinetochores attach to microtubule plus ends, thus allowing dynamic microtubules to properly segregate chromosomes. How this type of 'end-on' attachment between microtubule plus ends and kinetochores is formed and maintained is unclear. CENP-E, a kinesin-7 family member, is now shown to have a role in associating kinetochores with dynamic microtubule plus ends.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A potential model for the influence of lattice diffusion rate on plus-end-directed molecular motor tip tracking of depolymerizing microtubules.

References

  1. 1

    McIntosh, J. R., Grishchuk, E. L. & West, R. R. Annu. Rev. Cell Dev. Biol. 18, 193–219 (2002).

  2. 2

    Walczak, C. E., Cai, S. & Khodjakov, A. Nat. Rev. Mol. Cell Biol. 11, 91–102 (2010).

  3. 3

    Maiato, H., DeLuca, J., Salmon, E. D. & Earnshaw, W. C. J. Cell Sci. 117, 5461–5477 (2004).

  4. 4

    Rieder, C. L. & Salmon, E. D. Trends Cell Biol. 8, 310–318 (1998).

  5. 5

    Skibbens, R. V., Skeen, V. P. & Salmon, E. D. J. Cell Biol. 122, 859–875 (1993).

  6. 6

    Gudimchuk, N. et al. Nat. Cell Biol. 15, 1079–1088 (2013).

  7. 7

    Wood, K. W., Sakowicz, R., Goldstein, L. S. & Cleveland, D. W. Cell 91, 357–366 (1997).

  8. 8

    Gestaut, D. R. et al. Nat. Cell Biol. 10, 407–414 (2008).

  9. 9

    Gardner, M. K. & Odde, D. J. Nat. Cell Biol. 10, 379–381 (2008).

  10. 10

    Hill, T. L. Proc. Natl Acad. Sci. USA 82, 4404–4408 (1985).

  11. 11

    Bormuth, V., Varga, V., Howard, J. & Schaffer, E. Science 325, 870–873 (2009).

  12. 12

    Brouhard, G. J. et al. Cell 132, 79–88 (2008).

  13. 13

    Dixit, R. et al. Proc. Natl Acad. Sci. USA 106, 492–497 (2009).

  14. 14

    Schmidt, J. C. et al. Dev. Cell 23, 968–980 (2012).

  15. 15

    Powers, A. F. et al. Cell 136, 865–875 (2009).

Download references

Author information

Correspondence to Melissa K. Gardner.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gardner, M. CENP-E hangs on at dynamic microtubule ends. Nat Cell Biol 15, 1030–1032 (2013). https://doi.org/10.1038/ncb2836

Download citation