In the version of this Technical Report originally published, reference to a study (L. Wang et al. Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J. 32, 219–230; 2013) that used confocal microscopy to analyse the presence of phenotypically defined HSPCs in previously unreported and localized structures termed hemospheres, published while the current manuscript was under consideration, was inadvertently omitted. This has now been added as reference 42, and the following paragraph has been added to the Discussion section.
“While this publication was under revision, a study was published that described the existence of hemospheres, small and localized bone marrow regions enclosed within bone trabeculae in distal portions near the growth plate of femoral bones42. Hemospheres contain bone marrow microvessels, stromal cells of mesenchymal origin, haematopoietic cells and a small but significant fraction of perivascular HSPCs. Of note, HSPCs within hemospheres were exclusively found to rapidly expand in a clonal fashion during homeostasis and following transplantation post-irradiation42. It is therefore conceivable that hemospheres represent specific perivascular niches, with different instructive properties to those found in other perivascular HSPC microenvironments throughout the bone marrow cavity. Further defining the distinctive cellular and molecular features of hemospheres will be critical to ultimately determine the functional role of these previously unrecognized compartments.”
Furthermore, in the original version of this Technical Report, the e-mail address for the co-corresponding author César Nombela-Arrieta was incorrect, it should have read: Cesar.NombelaArrieta@childrens.harvard.edu.
These errors have now been corrected in the HTML and PDF versions of the Technical Report.
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Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Journal of Molecular Medicine (2017)