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Transmitting senescence to the cell neighbourhood

Nature Cell Biology volume 15, pages 887889 (2013) | Download Citation

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Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.

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Author information

Affiliations

  1. Matthew Hoare and Masashi Narita are at the Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK

    • Matthew Hoare
    •  & Masashi Narita

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Masashi Narita.

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DOI

https://doi.org/10.1038/ncb2811

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