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Polycomb complex recruitment in pluripotent stem cells

Nature Cell Biology volume 15, pages 348350 (2013) | Download Citation

The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

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Author information

Affiliations

  1. Center of Regenerative Medicine in Barcelona, Aiguader 88, E-08003 Barcelona, Spain

    • Maria J. Barrero
    •  & Juan Carlos Izpisua Belmonte
  2. Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037-1099 USA

    • Juan Carlos Izpisua Belmonte

Authors

  1. Search for Maria J. Barrero in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Juan Carlos Izpisua Belmonte.

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DOI

https://doi.org/10.1038/ncb2723

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