Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Rab10 joins the ER social network

The endoplasmic reticulum (ER) is a heterogeneous organelle with distinct morphologies of sheets and an interconnected network of tubules sharing a common lumen. An ER domain marked by the Rab10 GTPase and several lipid-synthesizing enzymes is implicated in dynamic ER tubule formation and fusion events in cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Rab10-mediated ER dynamics.

References

  1. Lin, S., Sun, S. & Hu, J. Int. J. Biochem. Cell Biol. 44, 1436–1443 (2012).

    Article  CAS  Google Scholar 

  2. Hu, J. et al. Cell 138, 549–561 (2009).

    Article  CAS  Google Scholar 

  3. Orso, G. et al. Nature 460, 978–983 (2009).

    Article  CAS  Google Scholar 

  4. Chen, S. Novick, P. & Ferro-Novick, S. Nat. Cell Biol. 14, 707–716 (2012).

    Article  CAS  Google Scholar 

  5. English, A. R. & Voeltz, G. K. Nat. Cell Biol. 15, 169–178 (2013).

    Article  CAS  Google Scholar 

  6. Kim, Y. J., Guzman-Hernandez, M. L. Balla, T. Dev. Cell 21, 813–824 (2011).

    Article  CAS  Google Scholar 

  7. Turner, M. D., Plutner, H. & Balch, W. E. J. Biol. Chem. 272, 13479–13483 (1997).

    Article  CAS  Google Scholar 

  8. Sandoval, C. O. & Simmen, T. Biochem. Soc. Trans. 40, 1426–1432 (2012).

    Article  CAS  Google Scholar 

  9. Chen, Y. et al. J. Cell Biol. 198, 545–560 (2012).

    Article  CAS  Google Scholar 

  10. Sasidharan, N. et al. Proc. Natl. Acad. Sci. USA 109, 18944–18949 (2012).

    Article  CAS  Google Scholar 

  11. Audhya, A., Desai, A. & Oemega, K. J. Cell Biol. 178, 43–56 (2007).

    Article  CAS  Google Scholar 

  12. Shi, A. et al. Proc. Natl. Acad. Sci. USA 109, E2306–E2315 (2012).

    Article  CAS  Google Scholar 

  13. Wagner, W., Brenowitz, S. D. & Hammer, J. A. III Nat. Cell Biol. 13, 40–50 (2011).

    Article  CAS  Google Scholar 

  14. Yoshimura, S., Gerondopoulos, A., Linford, A. Rigden, D. J. & Barr, F. A. J. Cell Biol. 191, 367–381 (2010).

    Article  CAS  Google Scholar 

  15. Wang, T. et al. Dev. Cell 21, 431–444 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Craig Blackstone.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, J., Blackstone, C. Rab10 joins the ER social network. Nat Cell Biol 15, 135–136 (2013). https://doi.org/10.1038/ncb2682

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2682

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing