Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Humans put their eggs in more than one basket

Nature Cell Biology volume 15, pages 13–15 (2013)Cite this article

Subjects

A Corrigendum to this article was published on 01 February 2013

Primordial germ cell (PGC) development in the human fetus remains relatively uncharted. A new study suggests that epigenetic reprogramming and sex differentiation in human PGCs occur asynchronously over an extended time period. This finding raises questions and implications for in vitro PGC differentiation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Comparison of models of PGC development in mice and humans.

References

  1. Laird, D. J, von Andrian, U. & Wagers, A. J. Cell 32, 612–30 (2008).

    Article  Google Scholar 

  2. Gkountela, S. et al. Nat. Cell Biol. 15, 113–122 (2013).

    Article  CAS  Google Scholar 

  3. Mintz, B. & Russell, E. S. J. Exp. Zool. Part A 134, 207–237 (1957).

    Article  CAS  Google Scholar 

  4. Stoop, H. et al. Hum. Reprod. 20, 1466–1476 (2005).

    Article  CAS  Google Scholar 

  5. Childs, A. J., Kinnell, H. L., He, J. & Anderson R. A. Stem Cells Dev. 21, 2343–2349 (2012).

    Article  CAS  Google Scholar 

  6. Bullejos, M. & Koopman, P : Mol. Reprod. Dev. 68, 422–428 (2004).

    Article  CAS  Google Scholar 

  7. Henderson, S. A. & Edwards, R. G. Nature 218, 22–28 (1968).

    Article  CAS  Google Scholar 

  8. Hajkova, P. et al. Nature 452, 877–881 (2008).

    Article  CAS  Google Scholar 

  9. Hayashi, K. & Surani, M. A. Cell Stem Cell 4, 493–498 (2009).

    Article  CAS  Google Scholar 

  10. Saitou, M., Kagiwada, S. & Kurimoto, K. Development 139, 15–31 (2012).

    Article  CAS  Google Scholar 

  11. Vincent, J. J. et al. PLoS ONE 6, e28960 (2011).

    Article  CAS  Google Scholar 

  12. Hayashi, K. et al. Science 338, 971–975 (2012).

    Article  CAS  Google Scholar 

  13. Hayashi, K. et al. Cell. 146, 519–532 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diana J. Laird is in the Department of Ob/Gyn, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Science, UCSF, 35 Medical Center Way, San Francisco, California 94143, USA,

    Diana J. Laird

Authors
  1. Diana J. Laird
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Diana J. Laird.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Laird, D. Humans put their eggs in more than one basket. Nat Cell Biol 15, 13–15 (2013). https://doi.org/10.1038/ncb2665

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2665

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing