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Nuanced junctional RhoA activity

RhoA signalling controls many diverse cellular processes, and thus discovering the mechanisms that determine its specific outcomes is a tantalizing challenge. A previously uncharacterized regulatory module operates selectively at the zonula adherens of epithelial cell junctions, in which positive and negative RhoA regulators are coordinated to fine-tune RhoA activity.

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Figure 1: Fine-tuning spatial patterns of RhoA activity.


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Correspondence to Rebecca A. Worthylake.

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Kher, S., Worthylake, R. Nuanced junctional RhoA activity. Nat Cell Biol 14, 784–786 (2012).

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