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Ubiquitin removal in the TGF-β pathway

The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.

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Figure 1: DUBs in the TGF-β pathway.


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Correspondence to Joan Massagué.

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Aggarwal, K., Massagué, J. Ubiquitin removal in the TGF-β pathway. Nat Cell Biol 14, 656–657 (2012).

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