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Holding on to stemness

Nature Cell Biology volume 14, pages 450–452 (2012)Cite this article

The attachment of stem cells to specialized functional niches instructs stem cell maintenance, with loss of adhesion associated with differentiation driven by cell-intrinsic programs. Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche.

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Figure 1: Critical role of Id in maintaining niche adhesion.

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Authors and Affiliations

  1. Justin D. Lathia is at the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA,

    Justin D. Lathia

  2. Justin D. Lathia and Jeremy N. Rich are at the Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA,

    Justin D. Lathia & Jeremy N. Rich

Authors
  1. Justin D. Lathia
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  2. Jeremy N. Rich
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Correspondence to Justin D. Lathia or Jeremy N. Rich.

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Lathia, J., Rich, J. Holding on to stemness. Nat Cell Biol 14, 450–452 (2012). https://doi.org/10.1038/ncb2498

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