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Good neighbours in the tumour stroma reduce oxidative stress

Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

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Figure 1: Metabolic interactions between CLL tumour cells and neighbouring bone marrow-derived stromal cells promote tumour cell survival.

References

  1. 1

    Tennant, D. A., Duran, R. V. & Gottlieb, E. Nat. Rev. Cancer 10, 267–277 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    CAS  Article  Google Scholar 

  3. 3

    Berardi, M. J. & Fantin, V. R. Curr. Opin. Genet. Dev. 21, 59–66 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Bhowmick, N. A. & Moses, H. L. Curr. Opin. Genet. Dev. 15, 97–101 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Zhang, W. et al. Nat. Cell Biol. 14, 276–286 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Ma, S. & Rosen, S. T. Curr. Opin. Oncol. 23, 601–608 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Silber, R. et al. Blood 80, 2038–2043 (1992).

    CAS  PubMed  Google Scholar 

  8. 8

    Biggers, J. D., Whittingham, D. G. & Donahue, R. P. Proc. Natl Acad. Sci. USA 58, 560–567 (1967).

    CAS  Article  Google Scholar 

  9. 9

    Pellerin, L. & Magistretti, P. J. J. Cereb. Blood Flow Metab. http://dx.doi.org/10.1038/jcbfm.2011.149 (2011).

  10. 10

    Sonveaux, P. et al. J. Clin. Invest. 118, 3930–3942 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. 11

    Kung, H. N., Marks, J. R. & Chi, J. T. PLoS Genet. 7, e1002229 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Eng, C. H., Yu, K., Lucas, J., White, E. & Abraham, R. T. Sci. Signal. 3, ra31 (2010).

    PubMed  Google Scholar 

  13. 13

    DeBerardinis, R. J. & Cheng, T. Oncogene 29, 313–324 (2010).

    CAS  Article  Google Scholar 

  14. 14

    Koglin, N. et al. Clin. Cancer Res. 17, 6000–6011 (2011).

    CAS  Article  Google Scholar 

  15. 15

    Jones, D. P. et al. FASEB J. 18, 1246–1248 (2004).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Ralph J. DeBerardinis.

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DeBerardinis, R. Good neighbours in the tumour stroma reduce oxidative stress. Nat Cell Biol 14, 235–236 (2012). https://doi.org/10.1038/ncb2449

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