Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.
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References
Tennant, D. A., Duran, R. V. & Gottlieb, E. Nat. Rev. Cancer 10, 267–277 (2010).
Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).
Berardi, M. J. & Fantin, V. R. Curr. Opin. Genet. Dev. 21, 59–66 (2011).
Bhowmick, N. A. & Moses, H. L. Curr. Opin. Genet. Dev. 15, 97–101 (2005).
Zhang, W. et al. Nat. Cell Biol. 14, 276–286 (2012).
Ma, S. & Rosen, S. T. Curr. Opin. Oncol. 23, 601–608 (2011).
Silber, R. et al. Blood 80, 2038–2043 (1992).
Biggers, J. D., Whittingham, D. G. & Donahue, R. P. Proc. Natl Acad. Sci. USA 58, 560–567 (1967).
Pellerin, L. & Magistretti, P. J. J. Cereb. Blood Flow Metab. http://dx.doi.org/10.1038/jcbfm.2011.149 (2011).
Sonveaux, P. et al. J. Clin. Invest. 118, 3930–3942 (2008).
Kung, H. N., Marks, J. R. & Chi, J. T. PLoS Genet. 7, e1002229 (2011).
Eng, C. H., Yu, K., Lucas, J., White, E. & Abraham, R. T. Sci. Signal. 3, ra31 (2010).
DeBerardinis, R. J. & Cheng, T. Oncogene 29, 313–324 (2010).
Koglin, N. et al. Clin. Cancer Res. 17, 6000–6011 (2011).
Jones, D. P. et al. FASEB J. 18, 1246–1248 (2004).
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DeBerardinis, R. Good neighbours in the tumour stroma reduce oxidative stress. Nat Cell Biol 14, 235–236 (2012). https://doi.org/10.1038/ncb2449
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DOI: https://doi.org/10.1038/ncb2449
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