Cancer-associated fibroblasts contribute to malignancy by expressing secreted pro-tumorigenic molecules. The microRNA miR-320 is now shown to be a crucial component of a PTEN-controlled tumour-suppressive axis in stromal fibroblasts. Loss of PTEN and miR-320 induces an oncogenic secretome that reprogrammes the tumour microenvironment to promote invasion and angiogenesis.
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Khew-Goodall, Y., Goodall, G. Stromal miR-320 keeps an oncogenic secretome in check. Nat Cell Biol 14, 124–125 (2012). https://doi.org/10.1038/ncb2431
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DOI: https://doi.org/10.1038/ncb2431
