Ras GTPases are tethered to cellular membranes by a farnesyl lipid that modifies a carboxy-terminal cysteine. One of the ways Ras traffics between membranes is via fluid-phase diffusion, suggesting that a cytosolic chaperone might be needed to shield the farnesyl lipid during transport. PDE6δ is now revealed to be a farnesyl-binding chaperone that facilitates the trafficking and signalling of Ras.
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Philips, M. Ras hitchhikes on PDE6δ. Nat Cell Biol 14, 128–129 (2012). https://doi.org/10.1038/ncb2429
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DOI: https://doi.org/10.1038/ncb2429
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