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SHARPINing integrin inhibition

Nature Cell Biology volume 13, pages 1292–1293 (2011)Cite this article

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The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins.

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Figure 1: Conformational changes determine integrin activity.

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Authors and Affiliations

  1. Mark D. Bass is at the School of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, UK,

    Mark D. Bass

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  1. Mark D. Bass
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Correspondence to Mark D. Bass.

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The author declares no competing financial interests.

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Bass, M. SHARPINing integrin inhibition. Nat Cell Biol 13, 1292–1293 (2011). https://doi.org/10.1038/ncb2368

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