The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through α-catenin reveals similarities with integrin regulation.
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Lecuit, T. α-catenin mechanosensing for adherens junctions. Nat Cell Biol 12, 522–524 (2010). https://doi.org/10.1038/ncb2066
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DOI: https://doi.org/10.1038/ncb2066
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