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TRIMming microRNA function in mouse stem cells

Nature Cell Biology volume 11, pages 1392–1393 (2009)Cite this article

MicroRNAs (miRNAs) regulate gene expression in many different organisms and cell types. In mouse embryonic stem cells, a regulatory circuit that involves let-7 and its target mLin41, which encodes an E3 ubiquitin ligase, facilitates polyubiquitylation of the miRNA effector Argonaute 2 (Ago2) and targets it for degradation.

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Figure 1: Regulatory circuits controlling let-7 activity in stem cells.

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Authors and Affiliations

  1. Anne Dueck and Gunter Meister are found at the Center for Integrated Protein Science Munich (CIPSM), Laboratory of RNA Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.,

    Anne Dueck & Gunter Meister

  2. Gunter Meister is also at the Universität Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany. gunter.meister@vkl.uni-regensburg.de,

    Gunter Meister

Authors
  1. Anne Dueck
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  2. Gunter Meister
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Dueck, A., Meister, G. TRIMming microRNA function in mouse stem cells. Nat Cell Biol 11, 1392–1393 (2009). https://doi.org/10.1038/ncb1209-1392

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