AP-1B: polarized sorting at the endosome

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Polarized epithelia require selective protein trafficking to establish and preserve distinct apical and basolateral surfaces. Recent work indicates that in polarized cells, the AP-1B clathrin adaptor recognizes certain basolateral targeting signals in an endosomal compartment where it seems to not only capture cargo but also promote recruitment of targeting and fusion machinery, ensuring accurate polarized sorting.

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Figure 1: Potential trafficking pathways for polarized sorting of AP-1B-dependent cargo.

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