Some kinesin motors can move along a microtubule for many hundred steps without dissociating. These motors are dimers, but precisely how the two motor domains are coordinated during stepping is still the subject of debate. A novel experimental approach offers new insights.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hancock, W.O. & Howard, J. in Molecular Motors (ed. Schliwa, M.) 243–269 (VCH-Wiley, Germany, 2003).
Gilbert, S.P., Webb, M.R., Brune, M. & Johnson, K.A. Nature 373, 671–676 (1995).
Hackney, D.D. Proc. Natl Acad. Sci. USA 91, 6865–6869 (1994).
Hua, W., Chung, J. & Gelles, J. Science 295, 844–848 (2002).
Kaseda, Higuchi and Hirose Nature Cell Biol. 5, 1079–1082 (2003).
Rosenfeld, S.S. et al. J. Biol. Chem. 278, 18550–18556 (2003).
Forkey, J.N. et al. Nature 422, 399–404 (2003).
Yildiz, A. et al. Science 300, 2061–2065 (2003).
Seeberger, C., Mandelkow, E. & Meyer, B. Biochemistry 39, 12558–12567 (2000).
Grummt, M. Woehlke, G., Henningsen, U., Fuchs, S., Schleicher, M. & Schliwa, M. EMBO J. 17, 5536–5542 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schliwa, M. Kinesin: walking or limping?. Nat Cell Biol 5, 1043–1044 (2003). https://doi.org/10.1038/ncb1203-1043
Issue Date:
DOI: https://doi.org/10.1038/ncb1203-1043
This article is cited by
-
Processive movement of single kinesins on crowded microtubules visualized using quantum dots
The EMBO Journal (2006)
-
Rapid double 8-nm steps by a kinesin mutant
The EMBO Journal (2004)