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Checkpoint signalling: focusing on 53BP1

Nature Cell Biology volume 4, pages E277–E279 (2002)Cite this article

The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

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Figure 1: Schematic representation of the 53BP1-dependent checkpoint pathway.

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  1. The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, CA, USA

    Robert T. Abraham

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Abraham, R. Checkpoint signalling: focusing on 53BP1. Nat Cell Biol 4, E277–E279 (2002). https://doi.org/10.1038/ncb1202-e277

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