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Holding back TOR advances mitosis

Nature Cell Biology volume 9, pages 1221–1222 (2007)Cite this article

The control of cell size through the coordination of cell growth and division is a longstanding fundamental problem. A study in fission yeast shows that TOR controls entry into mitosis through the MAP kinase Sty1 and so provides a molecular mechanism for the control of cell size.

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Figure 1: Control of cell size through the coordination of cell growth and division.
Figure 2: The signalling pathway by which Tor1 inhibits the onset of mitosis in response to nutrients (nitrogen).

References

  1. Jorgensen, P. & Tyers, M. Curr. Biol. 14, R1014–R1027 (2004).

    Article  CAS  Google Scholar 

  2. Fantes, P. & Nurse, P. Exp. Cell Res. 107, 377–386 (1977).

    Article  CAS  Google Scholar 

  3. Petersen, J. & Nurse, P. Nature Cell Biol. 9, 1263–1272 (2007).

    Article  CAS  Google Scholar 

  4. Wullschleger, S., Loewith, R. & Hall, M. N. Cell 124, 471–484 (2006).

    Article  CAS  Google Scholar 

  5. Nurse, P. Nature 344, 503–508 (1990).

    Article  CAS  Google Scholar 

  6. Petersen, J. & Hagan, I. M. Nature 435, 507–512 (2005).

    Article  CAS  Google Scholar 

  7. Manke, I. A. et al. Mol. Cell 17, 37–48 (2005).

    Article  CAS  Google Scholar 

  8. Lopez-Aviles, S. et al. Mol. Cell 17, 49–59 (2005).

    Article  CAS  Google Scholar 

  9. Alvarez, B. & Moreno, S. J. Cell Sci. 119, 4475–4485 (2006).

    Article  CAS  Google Scholar 

  10. Matsuo, T., Otsubo, Y., Urano, J., Tamanoi, F. & Yamamoto, M. Mol. Cell. Biol. 27, 3154–3164 (2007).

    Article  CAS  Google Scholar 

  11. Uritani, M. et al. Genes Cells 11, 1367–1379 (2006).

    Article  CAS  Google Scholar 

  12. Weisman, R., Roitburg, I., Schonbrun, M., Harari, R. & Kupiec, M. Genetics 175, 1153–1162 (2007).

    Article  CAS  Google Scholar 

  13. Helliwell, S. B., Howald, I., Barbet, N. & Hall, M. N. Genetics 148, 99–112 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Weisman, R. & Choder, M. J. Biol. Chem. 276, 7027–7032 (2001).

    Article  CAS  Google Scholar 

  15. Fingar, D. C., Salama, S., Tsou, C., Harlow, E. & Blenis, J. Genes Dev. 16, 1472–1487 (2002).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Thomas W. Sturgill is at the Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.,

    Thomas W. Sturgill

  2. Michael N. Hall is at the Biozentrum, University of Basel, Klingelbergstrasse 70, CH4056 Basel, Switzerland. m.hall@unibas.ch,

    Michael N. Hall

Authors
  1. Thomas W. Sturgill
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  2. Michael N. Hall
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Sturgill, T., Hall, M. Holding back TOR advances mitosis. Nat Cell Biol 9, 1221–1222 (2007). https://doi.org/10.1038/ncb1107-1221

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