Ubiquitin receptors that bind ubiquitinated proteins through ubiquitin-binding domains have key roles in various cellular processes. These receptors are often themselves monoubiquitinated, referred to as coupled monoubiquitination. Now, coupled monoubiquitination has been shown to involve monoubiquitination of a ubiquitin ligase and its subsequent interaction with a ubiquitin receptor.
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Haglund, K., Stenmark, H. Working out coupled monoubiquitination. Nat Cell Biol 8, 1218–1219 (2006). https://doi.org/10.1038/ncb1106-1218
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DOI: https://doi.org/10.1038/ncb1106-1218