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BTB proteins as henchmen of Cul3-based ubiquitin ligases

Nature Cell Biology volume 5, pages 950–951 (2003)Cite this article

The choice of ubiquitination substrates of Cul1- and Cul2-based E3 ubiquitin protein ligase complexes is dictated by the identity of their substrate-specific adaptors, known as F-box and BC-box proteins, respectively. Recent work suggests that members of the large family of BTB-domain proteins define a new class of substrate-specific adaptors of Cul3-based E3 complexes. This finding places many signalling pathways in which BTB-domain proteins participate under direct control of the ubiquitination pathway.

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Figure 1: Specific classes of substrate-specific adaptors serve distinct cullin-based E3s.

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  1. the Institute of Cell Biology, ETH-Hönggerberg, Zurich, CH-8093, Switzerland

    Wilhelm Krek

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  1. Wilhelm Krek
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Krek, W. BTB proteins as henchmen of Cul3-based ubiquitin ligases. Nat Cell Biol 5, 950–951 (2003). https://doi.org/10.1038/ncb1103-950

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