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Protein folding in vivo: the importance of ribosomes

Abstract

The folding of proteins into their native conformation is more favourable kinetically if it occurs at the same time as protein synthesis, but there are few examples of such co-translational folding. The folding of the Semliki Forest virus capsid protein is one example.

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Figure 1: Cross-section of basic thermodynamic funnels adapted to include the processes of protein biosynthesis and folding.

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Correspondence to Thomas O. Baldwin.

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Baldwin, T. Protein folding in vivo: the importance of ribosomes. Nat Cell Biol 1, E154–E155 (1999). https://doi.org/10.1038/14107

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