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Maintaining integrity

Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.

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Figure 1: Early events in the cellular response to double-strand breaks (DSBs) in the DNA.
Figure 2: Real-time imaging of the recruitment of signalling and repair proteins to microlaser-generated sites of DNA damage.


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Correspondence to Yosef Shiloh or Alan R. Lehmann.

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Shiloh, Y., Lehmann, A. Maintaining integrity. Nat Cell Biol 6, 923–928 (2004).

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