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Robo is Abl to block N-Cadherin function

Nature Cell Biology volume 4, pages E227–E229 (2002)Cite this article

The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.

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Figure 1: Cross-pathway inhibition prevents gridlock at the midline.
Figure 2: One possible in vivo role for the Robo-mediated inhibition of N-cadherin.

References

  1. Tessier-Lavigne, M. & Goodman, C. S. Science 274, 1123–1133 (1996).

    Article  CAS  PubMed  Google Scholar 

  2. Rhee, J., et al. Nature Cell Biol. 4, 691–704 (2002).

    Article  Google Scholar 

  3. Stein, E. & Tessier-Lavigne, M. Science 291, 1928–1938 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. Van Vactor, D. & Flanagan, J. Neuron 22, 649–652 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Rajagopalan, S., Vivancos, V., Nicolas, E. & Dickson, B. J. Cell 103, 1033–1045 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Simpson, J. H., Bland, K. S., Fetter, R. D. & Goodman, C. S. Cell 103, 1019–1032 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Rusch, J. & Van Vactor, D. Neuron 28, 637–640 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Tomaselli, K. J. et al. Neuron 1, 33–43 (1988).

    Article  CAS  PubMed  Google Scholar 

  9. Iwai, Y. et al. Neuron 19, 77–89 (1997).

    Article  CAS  PubMed  Google Scholar 

  10. Lilien, J., Balsamo, J., Arregui, C., & Xu, G. Develop. Dyn. 224, 18–29 (2002).

    Article  CAS  Google Scholar 

  11. Roura, S. et al. J. Biol. Chem. 274, 36734–36740 (1999).

    Article  CAS  PubMed  Google Scholar 

  12. Loreiro, J. & Peifer, M. Curr. Biol. 8, 622–632 (1998).

    Article  Google Scholar 

  13. Grevengoed, E. E., Loureiro, J. J., Jesse, T. L. & Peifer, M. J. Cell Biol. 155, 1185–1197 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bashaw, G. J. et al. Cell 101, 703–715 (2000).

    Article  CAS  PubMed  Google Scholar 

  15. Wills, P. et al. Neuron (in the press).

  16. Lin, D. M. et al. Neuron 13, 1055–1069 (1994).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. the Deptartment of Cell Biology and Program in Neuroscience at Harvard Medical School, Boston, 02115-5701, MA, USA

    Mark M. Emerson & David Van Vactor

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  1. Mark M. Emerson
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  2. David Van Vactor
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Emerson, M., Van Vactor, D. Robo is Abl to block N-Cadherin function. Nat Cell Biol 4, E227–E229 (2002). https://doi.org/10.1038/ncb1002-e227

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