The events of mitosis must occur in a precise sequence and in rapid succession to achieve proper chromosome segregation. At each key stage, mitotic checkpoints monitor whether everything is as it should be before proceeding, ensuring orderly progression through mitosis. Now, a new checkpoint has been identified that blocks anaphase onset in response to misoriented mitotic spindles.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Doe, C. Q. & Bowerman, B. Curr. Opin. Cell Biol. 13, 68–75 (2001).
Yeh, E., Skibbens, R. V., Cheng, J. W., Salmon, E. D. & Bloom, K. J. Cell Biol. 130, 687–700 (1995).
Oliferenko, S. & Balasubramanian, B. Nature Cell Biol. 4, 816–820 (2002).
Gachet, Y., Tournier, S., Millar, J. B. & Hyams, J. S. Nature 412, 352–355 (2001).
McCollum, D. & Gould, K. L Trends Cell Biol. 11, 89–95 (2001).
Bardin, A. J. & Amon, A. Nature Rev. Mol. Cell Biol. 2, 815–826 (2001).
O'Connell, C. B. & Wang, Y. L. Mol. Biol. Cell 11, 1765–1774 (2000).
Morgan, D. O. Nature Cell Biol. 1, E47–E53 (1999).
Holloway, S. L., Glotzer, M., King, R. W. & Murray, A. W. Cell 73, 1393–1402 (1993).
Surana, U. et al. EMBO J. 12, 1969–1978 (1993).
Wheatley, S. P. et al. J. Cell Biol. 138, 385–393 (1997).
Tran, P. T., Marsh, L., Doye, V., Inoue, S. & Chang, F. J. Cell Biol. 153, 397–411 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McCollum, D. First things first: spindle orientation and mitotic progression. Nat Cell Biol 4, E225–E226 (2002). https://doi.org/10.1038/ncb1002-e225
Issue Date:
DOI: https://doi.org/10.1038/ncb1002-e225