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Meiosis: Rec8 is the reason for cohesion

Nature Cell Biology volume 1, pages E125–E127 (1999)Cite this article

Abstract

During meiosis, sister chromatids produced by chromosome duplication are held together by Rec8, a meiosis-specific cohesion protein. Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion.

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Figure 1: Regulation of sister-chromatid cohesion in mitosis.
Figure 2: Regulation of sister-chromatid cohension in meiosis.

References

  1. Wanatabe, Y. & Nurse, P. Nature 400, 461–464 (1999).

    Article  Google Scholar 

  2. Klein, F. et al. Cell 98, 91–103 (1999).

    Article  CAS  Google Scholar 

  3. Uhlmann, F. & Nasmyth, K. Curr. Biol. 8, 1095–1101 (1998).

    Article  CAS  Google Scholar 

  4. Nasmyth, K. Trends Biochem. Sci. 24, 98–104 (1999).

    Article  CAS  Google Scholar 

  5. Uhlman, F., Lottspeich, F. & Nasmyth, K. Nature 400, 37–42 (1999).

    Article  Google Scholar 

  6. Peters, J.-M. Curr. Opin. Cell Biol. 10, 759–768 (1998).

    Article  CAS  Google Scholar 

  7. Zou, H., McGarry, T. J., Bernal, T., & Kirschner, M. W. Science 285, 418–422 (1999).

    Article  CAS  Google Scholar 

  8. Miyazaki, W. Y. & Orr-Weaver, T. L. Annu. Rev. Genet. 28, 167–187 (1994).

    Article  CAS  Google Scholar 

  9. Kerrebrock, A. W., Moore, D. P., Wu, J. S. & Orr-Weaver, T. L. Cell 83, 247–256 (1995).

    Article  CAS  Google Scholar 

  10. Dobson, M. J. et al. J. Cell. Sci. 107, 2749–2760 (1994).

    CAS  PubMed  Google Scholar 

  11. Parisi, S. et al. Mol. Cell. Biol. 19, 3515–3528 (1999).

    Article  CAS  Google Scholar 

  12. Klapholz, S. & Esposito, R. E. Genetics 96, 567–588 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17-233, Cambridge, 02139, Massachusetts, USA

    Chatanika Stoop-Myer & Angelika Amon

Authors
  1. Chatanika Stoop-Myer
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  2. Angelika Amon
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Correspondence to Angelika Amon.

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Stoop-Myer, C., Amon, A. Meiosis: Rec8 is the reason for cohesion. Nat Cell Biol 1, E125–E127 (1999). https://doi.org/10.1038/12956

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