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Close encounters of the LIM-kinase

Abstract

During cell movement, new actin structures are formed, under the orders of the small GTPase Rac. One of Rac’s orders is to inhibit the depolymerization of existing actin filaments. A chain of events from Rac to the inhibition of actin depolymerization has now been forged.

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Figure 1: Regulation of actin by the GTPase Rac.

References

  1. Edwards, D. C, Sanders, L. C., Bokoch, G. M. & Gill, G. N. Nature Cell Biol. 1, 253–259 (1999).

    Article  CAS  Google Scholar 

  2. Mackay, D. J. G. & Hall, A. J. Biol. Chem. 273, 20685–20688 (1998).

    Article  CAS  Google Scholar 

  3. Ren, X. D. & Schwartz, M. A. Curr. Opin. Genet. Dev. 8, 63–67 (1998).

    Article  CAS  Google Scholar 

  4. Miki, H., Suetsugu, S. & Takenawa, T. EMBO J. 17, 6932–6941 (1998).

    Article  CAS  Google Scholar 

  5. Bamburg, J. R., McGough, A. & Ohno, S. Trends Cell Biol. 9, 364–370 (1999).

    Article  CAS  Google Scholar 

  6. Arber, S. et al. Nature 393, 805–809 (1998).

    Article  CAS  Google Scholar 

  7. Yang, N. et al. Nature 393, 809–812 (1998).

    Article  CAS  Google Scholar 

  8. Manser, E. et al. Nature 367, 40–46 (1994).

    Article  CAS  Google Scholar 

  9. Abo, A. et al. EMBO J. 17, 6527–6540 (1998).

    Article  CAS  Google Scholar 

  10. Sells, M. A. et al. Curr. Biol. 7, 202–210 (1997).

    Article  CAS  Google Scholar 

  11. Manser, E. et al. Mol. Cell. Biol. 17, 1129–1143 (1997).

    Article  CAS  Google Scholar 

  12. Sells, M. A., Boyd, J. T. & Chernoff, J. J. Cell Biol. 145, 837–849 (1999).

    Article  CAS  Google Scholar 

  13. King, A. J. et al. Nature 396, 180–183 (1998).

    Article  CAS  Google Scholar 

  14. Frost, J. A. et al. EMBO J. 16, 6426–6438 (1997).

    Article  CAS  Google Scholar 

  15. Sanders, L. C., Matsumura, F., Bokoch, G. M. & de Lanerolle, P. Science 283, 2083–2085 (1999).

    Article  CAS  Google Scholar 

  16. Maekawa, M. et al. Science 285 895–898 (1999).

    Article  CAS  Google Scholar 

  17. Allen, K. M. et al. Nature Genet. 20, 25–30 (1998).

    Article  CAS  Google Scholar 

  18. Melzig, J. et al. Curr. Biol. 8, 1223–1226 (1998).

    Article  CAS  Google Scholar 

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Chernoff, J. Close encounters of the LIM-kinase. Nat Cell Biol 1, E115–E117 (1999). https://doi.org/10.1038/12942

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