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Twisted epithelial–mesenchymal transition blocks senescence

Nature Cell Biology volume 10, pages 10211023 (2008) | Download Citation

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The epithelial–mesenchymal transition (EMT) is a cellular transdifferentiation program that enables epithelial cancer cells to acquire traits of high-grade malignancy, notably invasive and metastatic powers. A new study indicates that it may also function early in tumour progression by preventing oncogene-induced senescence.

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Author information

Affiliations

  1. Robert A. Weinberg is at the Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, MIT Department of Biology, Cambridge MA 02142, USA.  weinberg@wi.mit.edu

    • Robert A. Weinberg

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DOI

https://doi.org/10.1038/ncb0908-1021

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