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A tal(in) of cell spreading

Nature Cell Biology volume 10, pages 10171019 (2008) | Download Citation

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Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function.

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Author information

Affiliations

  1. Margaret Frame is at the Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR.  m.frame@ed.ac.uk

    • Margaret Frame
  2. Jim Norman is at the Beatson Institute for Cancer Research, Glasgow Garscube Estate, Switchback Road, Glasgow G61 1BD.  j.norman@beatson.gla.ac.uk

    • Jim Norman

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DOI

https://doi.org/10.1038/ncb0908-1017

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