Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function.
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Frame, M., Norman, J. A tal(in) of cell spreading. Nat Cell Biol 10, 1017–1019 (2008). https://doi.org/10.1038/ncb0908-1017
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DOI: https://doi.org/10.1038/ncb0908-1017
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