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Tensin relief facilitates migration

Nature Cell Biology volume 9, pages 877–879 (2007)Cite this article

The molecular mechanisms through which the epidermal growth factor receptor (EGFR) promotes normal cell migration and carcinoma invasion are incompletely understood. A new study reveals that EGFR induces a switch in expression from tensin to its endogenous inhibitor cten (C-terminal tensin-like protein), alleviating integrin linkage to the cytoskeleton. Analysis of clinical samples suggests that this may be important for breast cancer invasion.

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Figure 1: Domain arrangement in tensin-3 and cten.
Figure 2: EGF induces a switch in cten and tensin-3 expression, which is important for migration in epithelial cells.

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Authors and Affiliations

  1. and the Sloan-Kettering Division, Yuliya Pylayeva is in the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Weill Graduate School of Medical Sciences, Cornell University, 15 East 69th Street, New York, NY 10021, USA.,

    Yuliya Pylayeva

  2. Filippo G. Giancotti is in the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. f-giancotti@ski.mskcc.org,

    Filippo G. Giancotti

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  1. Yuliya Pylayeva
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  2. Filippo G. Giancotti
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Pylayeva, Y., Giancotti, F. Tensin relief facilitates migration. Nat Cell Biol 9, 877–879 (2007). https://doi.org/10.1038/ncb0807-877

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