Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Balancing Mdm2 — a Daxx–HAUSP matter

Nature Cell Biology volume 8, pages 790–791 (2006)Cite this article

RING-finger ubiquitin ligases elicit ubiquitination of their substrates, which is balanced by their self-ubiquitination. New insights into regulating the switch between these two modes are illustrated by the role of the adaptor protein Daxx (death domain-associated protein) in regulating the deubiquitinating enzyme HAUSP which, in turn, directs the ligase activity of Mdm2.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Under non-stress conditions, Daxx associates with HAUSP and Mdm2, which results in stabilization of Mdm2 and MdmX and direction of Mdm2 ligase activity toward p53 that, in turn, leads to p53 ubiquitination and degradation.

References

  1. Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).

    Article  CAS  Google Scholar 

  2. Joazeiro, C.A. & Weissman, A.M. Cell 102, 549–552 (2000).

    Article  CAS  Google Scholar 

  3. Michael, D. & Oren, M. Semin. Cancer Biol. 13, 49–58 (2003).

    Article  CAS  Google Scholar 

  4. Tang et al. Nature Cell Biol. 8, 855–862 (2006).

    Article  CAS  Google Scholar 

  5. Li, M. et al. Nature 416, 648–653 (2002).

    Article  CAS  Google Scholar 

  6. Cummins, J.M. et al. Nature 428, 1 p following 486 (2004).

    Article  Google Scholar 

  7. Li, M., Brooks, C.L., Kon, N. & Gu, W. Mol. Cell 13, 879–886 (2004).

    Article  CAS  Google Scholar 

  8. Sheng, Y. et al. Nature Struct. Mol. Biol. 13, 285–291 (2006).

    Article  CAS  Google Scholar 

  9. Marine, J.C. & Jochemsen, A.G. Biochem. Biophys. Res. Commun. 331, 750–760 (2005).

    Article  CAS  Google Scholar 

  10. Pereg, Y. et al. Proc. Natl Acad. Sci. USA 102, 5056–5061 (2005).

    Article  CAS  Google Scholar 

  11. Zhao, L.Y. et al. J. Biol. Chem. 279, 50566–50579 (2004).

    Article  CAS  Google Scholar 

  12. Toledo, F. et al. Cancer Cell 9, 273–285 (2006).

    Article  CAS  Google Scholar 

  13. Buschmann, T., Lerner, D., Lee, C.G. & Ronai, Z. J. Biol. Chem. 276, 40389–40395 (2001).

    Article  CAS  Google Scholar 

  14. Chen, A. et al. J. Cell. Biochem. 98, 895–911 (2006).

    Article  CAS  Google Scholar 

  15. Fuchs, S. Y, et al. Genes Dev. 12, 2658–2663 (1998).

    Article  CAS  Google Scholar 

  16. Yang, X., Khosravi-Far, R., Chang, H.Y. & Baltimore, D. Cell 89, 1067–1076 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA

    Ze´ev Ronai

Authors
  1. Ze´ev Ronai
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ronai, Z. Balancing Mdm2 — a Daxx–HAUSP matter. Nat Cell Biol 8, 790–791 (2006). https://doi.org/10.1038/ncb0806-790

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0806-790

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing