Cell migration requires that Rac GTPases promote formation of actin polymers at the cell's leading edge. An activator of Rac, DOCK180, accomplishes this localization by using its DHR-1 domain to bind phosphatidylinositol-3,4,5-trisphosphate at the membrane.
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Bourne, H. Rac and cell migration: CDM proteins integrate signals. Nat Cell Biol 7, 777–778 (2005). https://doi.org/10.1038/ncb0805-777
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DOI: https://doi.org/10.1038/ncb0805-777