Developmental quiescence: Cdc14 moonlighting in G1

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Cdc14 is a phosphatase that can antagonize CDK/cyclin cell-cycle functions. New insights from Caenorhabditis elegans show that CDC-14 is required to prevent cell-cycle entry during extended periods of developmentally regulated quiescence, and also clarify its role in creating the central mitotic spindle during anaphase.

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Figure 1: One function of CDC-14 in C. elegans is to maintain the G1-phase arrest of cells during larval development.
Figure 2: CDC-14 also contributes to central spindle formation.

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Kipreos, E. Developmental quiescence: Cdc14 moonlighting in G1. Nat Cell Biol 6, 693–695 (2004) doi:10.1038/ncb0804-693

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