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The sirens' call

Cells dying by apoptosis acquire 'eat me' signals and lose 'don't eat me' signals to trigger recognition and uptake by phagocytes. How do these sirens of death call the macrophages into a site of massive cell death during tissue remodelling? Release of soluble chemotactic factors, including lysophosphatidylcholine, seems to be the sirens' call.

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Figure 1: LPC mediates attraction of macrophages towards apoptotic cells.

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Fadok, V. The sirens' call. Nat Cell Biol 5, 697–699 (2003). https://doi.org/10.1038/ncb0803-697

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