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Signalling and endocytosis: Wnt breaks down on back roads

How are Wnt signals made effective in only the right times and places? New studies of the asymmetrical influences of Wnt signals originating from a source show the importance of differential signal degradation and regulated endocytosis.

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Figure 1: Wingless signalling and pattern formation during fly embryogenesis.

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Scott, M. Signalling and endocytosis: Wnt breaks down on back roads. Nat Cell Biol 3, E185–E186 (2001). https://doi.org/10.1038/35087126

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