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The origin of CDK regulation

Nature Cell Biology volume 3, pages E182–E184 (2001)Cite this article

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

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Figure 1: Recruitment of cyclin E/Cdk2/Xic1 and SCF to replication origins.
Figure 2: Different positive feedback loops for regulating Kip degradation in somatic and early embryonic cells.

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Authors and Affiliations

  1. the CRC Chromsome Replication Research Group, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, UK

    Anatoliy Li & J. Julian Blow

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  1. Anatoliy Li
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  2. J. Julian Blow
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Li, A., Blow, J. The origin of CDK regulation. Nat Cell Biol 3, E182–E184 (2001). https://doi.org/10.1038/35087119

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