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LAP proteins: what’s up with epithelia?

Abstract

How cells maintain their overall shape and size, and the related questionof how proteins and other molecules reach and stay at their specific subcellularlocations, are among the most difficult and exciting problems in cell biology.Three recent studies have made a significant contribution to this area byidentifying new proteins, called LAP proteins, that have critical functionsin maintaining the shape and apical-basal polarity of epithelial cells.

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Figure 1: The domains and junctions of epithelial cells. Adherens junctions (AJ)contain the most important cell–cell adhesion molecules, the cadherins,as well as Armadillo and many proteins that are involved in cell–cellsignalling.
Figure 2: Domain structures of the LAP proteins described in this report.

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Correspondence to Peter J. Bryant.

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Bryant, P., Huwe, A. LAP proteins: what’s up with epithelia?. Nat Cell Biol 2, E141–E143 (2000). https://doi.org/10.1038/35019616

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