Abstract
Regulated protein degradation in eukaryotes occurs principally through covalent tagging of substrates with ubiquitin, thereby targeting them for destruction by 26S proteasomes. Classical allostery has now been added to the repertoire of mechanisms that can modulate ubiquitin tagging, allowing feed-forward regulation to be achieved through targeted protein destruction.
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Pickart, C. Ubiquitin biology: an old dog learns an old trick. Nat Cell Biol 2, E139–E140 (2000). https://doi.org/10.1038/35019610
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DOI: https://doi.org/10.1038/35019610
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