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Nuclear transport HEATs up


Importins, proteins that transport macromolecules into the nucleus, interact with cargo and regulatory molecules at different times in the transport cycle. We are now closer to understanding the structural basis of these interactions.

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Figure 1: Nuclear import of proteins containing different basic nuclear-localization sequences (NLSs) by importin-β.


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Correspondence to Pamela A. Silver.

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Brodsky, A., Silver, P. Nuclear transport HEATs up. Nat Cell Biol 1, E66–E67 (1999).

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