Stress fibres take shape

Abstract

The GTPase Rho is well known for its ability to induce the assembly of stress fibres. Two interacting targets of Rho, ROCK and Dia1, have been found to act in concert to mediate this response to Rho.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A model for how ROCK and Dia1 cooperate to mediate Rho-induced stress-fibre formation.

References

  1. 1

    Burridge, K. & Chrzanowska-Wodnicka, M. Annu. Rev. Cell Dev. Biol. 12, 463–519 (1996).

  2. 2

    Aspenström, P. Curr. Opin. Cell Biol. 11, 95–102 (1999).

  3. 3

    Sahai, E., Alberts, A. S. & Treisman, R. EMBO J. 17, 1350–1361 (1998).

  4. 4

    Watanabe, N., Kato, T., Fujita, A., Ishizaki, T. & Narumiya, S. Nature Cell Biol. 1, 136–143 (1999).

  5. 5

    Tapon, N. & Hall, A. Curr. Opin. Cell Biol. 9, 86–92 (1997).

  6. 6

    Uehata, M. et al. Nature 389, 990–994 (1997).

  7. 7

    Matsui, T. et al. J. Cell Biol. 140, 647–657 (1998).

  8. 8

    Mackay, D. J., Esch, F., Furthmayr, H. & Hall, A. J. Cell Biol. 138, 927–938 (1997).

  9. 9

    Kimura, K. et al. J. Biol. Chem. 273, 5542–5548 (1998).

  10. 10

    Tominaga, T., Ishizaki, T., Narumiya, S. & Barber, D. L. EMBO J. 17, 4712–4722 (1998).

  11. 11

    Wasserman, S. Trends Cell Biol. 8, 111–115 (1998).

  12. 12

    Zigmond, S. H. Curr. Opin. Cell Biol. 8, 66–73 (1996).

  13. 13

    Machesky, L. M. & Hall, A. J. Cell Biol. 138, 913–926 (1997).

  14. 14

    Toker, A. Curr. Opin. Cell Biol. 10, 254–261 (1998).

  15. 15

    Vincent, S. & Settleman, J. Mol. Cell. Biol. 17, 2247–2256 (1997).

  16. 16

    Du, W., Lebowitz, P. F. & Prendergast, G. C. Mol. Cell. Biol. 19, 1831–1840 (1999).

Download references

Author information

Correspondence to Anne J. Ridley.

Rights and permissions

Reprints and Permissions

About this article

Further reading