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Actin's latest act: polymerizing to facilitate transcription?

Actin and actin-binding factors have been implicated in nuclear processes such as chromatin remodelling, mRNA processing and export, and transcription. Until now, actin was assumed to function in these processes as a monomer; however, new work suggests that polymerized actin and its effectors may also be important, particularly in transcription.

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Figure 1: Actin may modulate several steps in mRNA synthesis, either as a monomer or as a polymer.

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Vieu, E., Hernandez, N. Actin's latest act: polymerizing to facilitate transcription?. Nat Cell Biol 8, 650–651 (2006). https://doi.org/10.1038/ncb0706-650

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