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Endosome sorting: GSE complex minds the Gap

The general amino acids permease Gap1p provides yeast with sufficient amino acids to maintain protein synthesis. Gap1p is translocated to the plasma membrane when amino acids become limiting, a process that is mediated by a newly identified membrane complex called the GSE complex.

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Figure 1: Regulated trafficking of Gap1p under either nitrogen-rich or nitrogen-poor conditions.
Figure 2: Assembly of the GSE complex.

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Seaman, M. Endosome sorting: GSE complex minds the Gap. Nat Cell Biol 8, 648–649 (2006). https://doi.org/10.1038/ncb0706-648

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