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Unravelling mRNA export

Nature Cell Biology volume 8, pages 645–647 (2006)Cite this article

Precise spatial regulation of mRNA remodelling is crucial for proper gene expression. One way this is accomplished is through activation of the DEAD-box helicase Dbp5 at the cytoplasmic fibrils of the nuclear-pore complex, by the nucleoporin Gle1 and the soluble inositol polyphosphate InsP6.

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Figure 1: Dbp5 is selectively activated on the cytoplasmic fibrils of the NPC.

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Authors and Affiliations

  1. Departments of Biochemistry and Genetics, Dartmouth Medical School, Hanover, 03755, NH, USA

    Charles N. Cole

  2. Department of Biochemistry, Dartmouth Medical School, Hanover, 03755, NH, USA

    John J. Scarcelli

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  1. Charles N. Cole
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  2. John J. Scarcelli
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Cole, C., Scarcelli, J. Unravelling mRNA export. Nat Cell Biol 8, 645–647 (2006). https://doi.org/10.1038/ncb0706-645

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